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Application of small coater in gel coating

Abstract: 本文探讨了小型涂布机在涂凝胶贴膏生产中的应用,重点介绍了其工作原理、结构特点以及实际应用案例。小型涂布机通过机械或电子控制,均匀涂覆液态或半液态涂料于基材表面,涵盖了涂布、干燥和复卷三个主要步骤。其结构包括供料系统、涂布系统、干燥系统、传动系统和控制系统,具有结构紧凑、操作简便、精度高等优点,适用于实验室和小规模生产。文章详细描述了涂凝胶贴膏的涂料选择、工艺优化及实际应用案例,如医疗器械公司和药物研发实验室的成功经验。优化涂布工艺和涂料配方对于提高涂凝胶贴膏的质量和效果尤为重要。总结认为,小型涂布机在涂凝胶贴膏生产中具有广阔的应用前景。

In recent years, gel patches have been widely used in the field of medical and daily care due to their portability, ease of use, and remarkable effects. The small coater plays an important role as a key equipment for the production of gel paste. This article will discuss in detail the application of small coating machine in gel paste from the aspects of its principle, structure, characteristics, application scenarios and practical cases.

The working principle of the small coater

A small coater is a device that evenly coats a liquid or semi-liquid coating on the surface of a substrate through mechanical or electronic control. The basic working process consists of three main steps: coating, drying and rewinding. First, the paint is evenly distributed on the surface of the substrate by means of a coating head or nozzle. Next, the solvent in the coating is evaporated by a drying device (such as hot air drying, infrared drying, etc.) to solidify the coating on the surface of the substrate. Finally, the substrate that has been coated and dried is rewound into a roll for further processing and use.

Structure and characteristics of a small coater

The small coater is usually composed of five main parts: feeding system, coating system, drying system, transmission system and control system. The feeding system is responsible for storing and transporting the paint, including bins, pumps, piping, etc. The coating system is the core part, including the coating head, nozzle, coating roller, etc., which determines the uniformity and thickness of the coating. The drying system includes a Drying Oven, heater, fan, etc., which is used to quickly dry the coating. The drive system is responsible for the conveying and positioning of the substrate, including conveyor belts, guide rollers, motors, etc. The control system includes PLC controllers, sensors, displays, etc., which are used to control and monitor the entire coating process.

The small coater has the characteristics of compact structure, easy operation, high precision and strong adaptability. It has a small footprint and is suitable for laboratory and small-scale production; Intelligent control system, simple operation and easy to use; Through the precision coating head and control system, the uniformity and thickness consistency of the coating are ensured; Suitable for a wide range of substrates and coatings with a wide range of applications.

Analysis of the application of small coater in gel paste with Figure 1

The application of small coaters in applying gel pastes

Paint selection

The main components of gel patches are drugs, matrices and additives, and the common matrices are water-soluble polymer materials and fat-soluble polymer materials. Depending on the pharmaceutical ingredient and treatment needs, it is important to choose the right coating formulation. Common water-soluble coatings include polyvinyl alcohol (PVA), hydroxypropyl methyl cellulose (HPMC), etc., which are suitable for water-soluble drugs; Fat-soluble coatings include polyacrylic acid (PAA), silicone, etc., which are suitable for fat-soluble drugs.

Coating process

The optimization of the coating process is a key part of ensuring the quality of the gel paste, including the control of parameters such as coating speed, coating thickness, drying temperature and drying time. The coating speed affects the uniformity and thickness of the coating and is generally adjusted according to the characteristics of the substrate and the coating. The thickness of the coating directly affects the drug content and application effect of the plaster, which is usually controlled by adjusting the gap and pressure of the coating head. The drying temperature and time affect the curing quality and production efficiency of the coating and need to be set according to the volatility and curing characteristics of the coating.

Application examples

A medical device company uses a small coater for the production of gel patches. By optimizing the coating process, the company has succeeded in producing a uniform and consistent thickness gel patch that has been well received by the market. The specific process parameters are as follows: the coating speed is 10 m/min, the coating thickness is 100 microns, the drying temperature is 60 degrees Celsius, and the drying time is 10 minutes.

Another example is the experimental study of a new type of drug patch in a drug discovery laboratory using a small coating machine. By precisely controlling the coating thickness and drying time, the laboratory has successfully prepared a variety of plasters with different drug content and drug release characteristics, which provides important data support for the development of new drugs.

conclusion

The small coater has a promising application in applying gel pastes, and its compact structure, ease of operation and high-precision coating effect make it a device for laboratory research and small-scale production. By optimizing the coating selection and application process, the quality and application of gel plasters can be significantly improved.

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