In packaging printing, in order to achieve special decoration and anti-counterfeiting effects, it is often used to print with spot color inks in addition to 4-color printing, such as gold, silver inks and special inks of other special colors. The use of spot color inks can not only solve the problems of overprinting and water-ink balance control in ordinary four-color printing, but also ensure that the printed matter has stable and consistent color, bright colors, good brightness, and accurate hue. Spot color ink printing can also achieve special creative and anti-counterfeiting printing effects. Therefore, spot color inks are widely used in packaging printing. Although spot color inks are mostly prepared by various color inks other than the series produced by ink manufacturers, sometimes printing manufacturers also need to prepare spot color inks in order to meet customer requirements and special printing effects. Due to the differences in the hue and characteristics of the inks produced by different manufacturers, the substrates used are varied. Therefore, in order to print satisfactory results, not only must the matching be qualified, but also the use must be accurate, so as to ensure the printing quality. The following is an introduction to the methods of avoiding color difference and other problems in the use of spot color inks.